Role of hyperphosphatemia and 1, 25-dihydroxyvitamin D in vascular calcification and mortality in fibroblastic growth factor 23 null mice
Abstract Fibroblastic growth factor 23 (FGF23) regulates renal phosphate reabsorption and
1α-hydroxylase activity. Ablation of FGF23 results in elevated serum phosphate, calcium,
and 1, 25-dihydroxyvitamin D3 [1, 25 (OH) 2 D] levels; vascular calcifications; and early
death. For determination of the independent roles of hyperphosphatemia and excess vitamin
D activity on the observed phenotypic abnormalities, FGF23 null mice were fed a phosphate-
or vitamin D–deficient diet. The phosphate-deficient diet corrected the hyperphosphatemia …
1α-hydroxylase activity. Ablation of FGF23 results in elevated serum phosphate, calcium,
and 1, 25-dihydroxyvitamin D3 [1, 25 (OH) 2 D] levels; vascular calcifications; and early
death. For determination of the independent roles of hyperphosphatemia and excess vitamin
D activity on the observed phenotypic abnormalities, FGF23 null mice were fed a phosphate-
or vitamin D–deficient diet. The phosphate-deficient diet corrected the hyperphosphatemia …