[HTML][HTML] p38 MAP kinase and MAPKAP kinases MK2/3 cooperatively phosphorylate epithelial keratins
The MAPK-activated protein kinases (MAPKAP kinases) MK2 and MK3 are directly activated
via p38 MAPK phosphorylation, stabilize p38 by complex formation, and contribute to the
stress response. The list of substrates of MK2/3 is increasing steadily. We applied a
phosphoproteomics approach to compare protein phosphorylation in MK2/3-deficient cells
rescued or not by ectopic expression of MK2. In addition to differences in phosphorylation of
the known substrates of MK2, HSPB1 and Bag-2, we identified strong differences in …
via p38 MAPK phosphorylation, stabilize p38 by complex formation, and contribute to the
stress response. The list of substrates of MK2/3 is increasing steadily. We applied a
phosphoproteomics approach to compare protein phosphorylation in MK2/3-deficient cells
rescued or not by ectopic expression of MK2. In addition to differences in phosphorylation of
the known substrates of MK2, HSPB1 and Bag-2, we identified strong differences in …