DNA adducts in skin biopsies and 1-hydroxypyrene in urine of psoriasis patients and healthy volunteers following treatment with coal tar
JHJ Roelofzen, PGM van der Valk, R Godschalk… - Toxicology letters, 2012 - Elsevier
Coal tar ointments (CTO) are frequently used in the treatment of psoriasis and eczema, but
CTO contain carcinogenic polycyclic aromatic hydrocarbons (PAH). PAH are absorbed and
metabolized in the skin. In psoriasis, the skin barrier is altered and therefore, absorption and
metabolism of PAH may differ from healthy skin. In this study, levels of urinary 1-
hydroxypyrene and PAH-DNA adducts in the skin were studied in psoriatic patients and
healthy volunteers. Three punch biopsies were taken from the lower back of 10 male …
CTO contain carcinogenic polycyclic aromatic hydrocarbons (PAH). PAH are absorbed and
metabolized in the skin. In psoriasis, the skin barrier is altered and therefore, absorption and
metabolism of PAH may differ from healthy skin. In this study, levels of urinary 1-
hydroxypyrene and PAH-DNA adducts in the skin were studied in psoriatic patients and
healthy volunteers. Three punch biopsies were taken from the lower back of 10 male …