[HTML][HTML] Evaluation of a transgenic mouse model of multiple sclerosis with noninvasive methods
M Enriquez-Algeciras, D Ding, TH Chou… - … & visual science, 2011 - iovs.arvojournals.org
Investigative ophthalmology & visual science, 2011•iovs.arvojournals.org
Methods.: Assessment of neurologic/behavioral abnormalities was made using pattern
electroretinogram (PERG), magnetic resonance imaging (MRI), optic coherence tomography
(OCT), and end point histologic analysis. Results.: Electrophysiologic (PERG) recordings
demonstrated functional deficits in vision commensurate with neurologic/behavioral
abnormalities. In ND4 mice, the authors found PERG abnormalities preceded
neurologic/gait abnormalities. MRI demonstrated subtle structural changes that progressed …
electroretinogram (PERG), magnetic resonance imaging (MRI), optic coherence tomography
(OCT), and end point histologic analysis. Results.: Electrophysiologic (PERG) recordings
demonstrated functional deficits in vision commensurate with neurologic/behavioral
abnormalities. In ND4 mice, the authors found PERG abnormalities preceded
neurologic/gait abnormalities. MRI demonstrated subtle structural changes that progressed …
Methods.: Assessment of neurologic/behavioral abnormalities was made using pattern electroretinogram (PERG), magnetic resonance imaging (MRI), optic coherence tomography (OCT), and end point histologic analysis.
Results.: Electrophysiologic (PERG) recordings demonstrated functional deficits in vision commensurate with neurologic/behavioral abnormalities. In ND4 mice, the authors found PERG abnormalities preceded neurologic/gait abnormalities. MRI demonstrated subtle structural changes that progressed over time in correlation with behavioral abnormalities.
Conclusions.: The ND4 mouse model has been evaluated using well-defined parameters of noninvasive methods (PERG, MRI, and OCT), enabling objective identification of functional and structural deficits and their correlation with neurologic/gait abnormality.
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