Extracellular Release of Antigenic Proteins byHelicobacter pylori
P Cao, MS McClain, MH Forsyth… - Infection and immunity, 1998 - Am Soc Microbiol
P Cao, MS McClain, MH Forsyth, TL Cover
Infection and immunity, 1998•Am Soc MicrobiolScreening a Helicobacter pylori genomic library with antisera raised against H. pylori broth
culture supernatant resulted in the identification of six antigens: urease, HspB, Lpp20, DnaK,
MsrA, and a cysteine-rich 28-kDa protein (designated HcpA). H. pylori antigens may be
released into the extracellular space by multiple mechanisms, including specific secretion
pathways, autolysis, and membrane vesicle formation.
culture supernatant resulted in the identification of six antigens: urease, HspB, Lpp20, DnaK,
MsrA, and a cysteine-rich 28-kDa protein (designated HcpA). H. pylori antigens may be
released into the extracellular space by multiple mechanisms, including specific secretion
pathways, autolysis, and membrane vesicle formation.
Abstract
Screening a Helicobacter pylori genomic library with antisera raised against H. pylori broth culture supernatant resulted in the identification of six antigens: urease, HspB, Lpp20, DnaK, MsrA, and a cysteine-rich 28-kDa protein (designated HcpA). H. pylori antigens may be released into the extracellular space by multiple mechanisms, including specific secretion pathways, autolysis, and membrane vesicle formation.
American Society for Microbiology