[HTML][HTML] Splenic macrophages maintain the anti‐platelet autoimmune response via uptake of opsonized platelets in patients with immune thrombocytopenic purpura
M Kuwana, Y Okazaki, Y Ikeda - Journal of Thrombosis and Haemostasis, 2009 - Elsevier
Background: Immune thrombocytopenic purpura (ITP) is an autoimmune disease primarily
caused by IgG anti‐platelet autoantibodies. Activation of autoreactive CD4+ T cells upon
recognition of cryptic GPIIb/IIIa peptides presented by antigen‐presenting cells (APCs) is a
critical step for triggering and maintaining the pathogenic anti‐platelet autoantibody
response. Objectives: We investigated which APCs carry the cryptic peptides of GPIIb/IIIa
that activate autoreactive CD4+ T cells in ITP patients. Methods: GPIIb/IIIa‐reactive T‐cell …
caused by IgG anti‐platelet autoantibodies. Activation of autoreactive CD4+ T cells upon
recognition of cryptic GPIIb/IIIa peptides presented by antigen‐presenting cells (APCs) is a
critical step for triggering and maintaining the pathogenic anti‐platelet autoantibody
response. Objectives: We investigated which APCs carry the cryptic peptides of GPIIb/IIIa
that activate autoreactive CD4+ T cells in ITP patients. Methods: GPIIb/IIIa‐reactive T‐cell …