Antigen receptor signaling to NF-κB via CARMA1, BCL10, and MALT1
M Thome, JE Charton, C Pelzer… - Cold Spring Harbor …, 2010 - cshperspectives.cshlp.org
M Thome, JE Charton, C Pelzer, S Hailfinger
Cold Spring Harbor perspectives in biology, 2010•cshperspectives.cshlp.orgThe signaling pathway controlling antigen receptor-induced regulation of the transcription
factor NF-κB plays a key role in lymphocyte activation and development and the generation
of lymphomas. Work of the past decade has led to dramatic progress in the identification and
characterization of new players in the pathway. Moreover, novel enzymatic activities relevant
for this pathway have been discovered, which represent interesting drug targets for immuno-
suppression or lymphoma treatment. Here, we summarize these findings and give an …
factor NF-κB plays a key role in lymphocyte activation and development and the generation
of lymphomas. Work of the past decade has led to dramatic progress in the identification and
characterization of new players in the pathway. Moreover, novel enzymatic activities relevant
for this pathway have been discovered, which represent interesting drug targets for immuno-
suppression or lymphoma treatment. Here, we summarize these findings and give an …
The signaling pathway controlling antigen receptor-induced regulation of the transcription factor NF-κB plays a key role in lymphocyte activation and development and the generation of lymphomas. Work of the past decade has led to dramatic progress in the identification and characterization of new players in the pathway. Moreover, novel enzymatic activities relevant for this pathway have been discovered, which represent interesting drug targets for immuno-suppression or lymphoma treatment. Here, we summarize these findings and give an outlook on interesting open issues that need to be addressed in the future.
cshperspectives.cshlp.org