[HTML][HTML] Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36α, IL-36β, and IL-36γ) or antagonist (IL-36Ra) activity

JE Towne, BR Renshaw, J Douangpanya… - Journal of Biological …, 2011 - ASBMB
IL-36α, IL-36β, and IL-36γ (formerly IL-1F6, IL-1F8, and IL-1F9) are IL-1 family members that
signal through the IL-1 receptor family members IL-1Rrp2 (IL-1RL2) and IL-1RAcP. IL-36Ra
(formerly IL-1F5) has been reported to antagonize IL-36γ. However, our previous attempts to
demonstrate IL-36Ra antagonism were unsuccessful. Here, we demonstrate that IL-36Ra
antagonist activity is dependent upon removal of its N-terminal methionine. IL-36Ra starting
at Val-2 is fully active and capable of inhibiting not only IL-36γ but also IL-36α and IL-36β …