Cocaine stimulates adrenocorticotropin (ACTH) secretion through a corticotropin-releasing factor (CRF)-mediated mechanism
C Rivier, W Vale - Brain research, 1987 - Elsevier
C Rivier, W Vale
Brain research, 1987•ElsevierCocaine was injected intravenously to non-anesthetized, freely moving adult male rats and
caused dose-dependent elevations in plasma adrenocorticotropin (ACTH) levels. The
observation that this stimulatory effect was completely abolished by pretreatment with a
corticotropin-releasing factor (CRF) antiserum, coupled with the lack of effect of cocaine on
ACTH secretion by cultured pituitary cells, suggests that cocaine acts within the brain to
release endogenous CRF.
caused dose-dependent elevations in plasma adrenocorticotropin (ACTH) levels. The
observation that this stimulatory effect was completely abolished by pretreatment with a
corticotropin-releasing factor (CRF) antiserum, coupled with the lack of effect of cocaine on
ACTH secretion by cultured pituitary cells, suggests that cocaine acts within the brain to
release endogenous CRF.
Abstract
Cocaine was injected intravenously to non-anesthetized, freely moving adult male rats and caused dose-dependent elevations in plasma adrenocorticotropin (ACTH) levels. The observation that this stimulatory effect was completely abolished by pretreatment with a corticotropin-releasing factor (CRF) antiserum, coupled with the lack of effect of cocaine on ACTH secretion by cultured pituitary cells, suggests that cocaine acts within the brain to release endogenous CRF.
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