Stress-induced cocaine craving and hypothalamic-pituitary-adrenal responses are predictive of cocaine relapse outcomes
R Sinha, M Garcia, P Paliwal, MJ Kreek… - Archives of general …, 2006 - jamanetwork.com
Background Cocaine dependence is associated with high rates of relapse. Stress and drug
cue exposure are known to increase cocaine craving and stress arousal, but the association
between these responses and cocaine relapse has not been previously studied. Objective
To examine whether stress-induced and drug cue–induced cocaine craving and
hypothalamic-pituitary-adrenal axis responses evoked in the laboratory are associated with
subsequent cocaine relapse. Design Prospective study design assessing cocaine relapse …
cue exposure are known to increase cocaine craving and stress arousal, but the association
between these responses and cocaine relapse has not been previously studied. Objective
To examine whether stress-induced and drug cue–induced cocaine craving and
hypothalamic-pituitary-adrenal axis responses evoked in the laboratory are associated with
subsequent cocaine relapse. Design Prospective study design assessing cocaine relapse …
