Genetic variants altering dopamine D2 receptor expression or function modulate the risk of opiate addiction and the dosage requirements of methadone substitution
A Doehring, N von Hentig, J Graff… - Pharmacogenetics …, 2009 - journals.lww.com
Aim Addictive behavior is importantly mediated by mesolimbic dopaminergic signaling.
Here, we comprehensively analyzed the DRD2 gene locus, and in addition, the ANKK1
rs1800497C> T single nucleotide polymorphism (SNP), formerly known as 'dopamine D 2
receptor Taq1A C> T polymorphism', for associations with the risk of opiate addiction and the
methadone dosage requirements. Methods Allelic frequencies of DRD2/ANKK1
polymorphisms were compared between 85 methadone-substituted Caucasian patients and …
Here, we comprehensively analyzed the DRD2 gene locus, and in addition, the ANKK1
rs1800497C> T single nucleotide polymorphism (SNP), formerly known as 'dopamine D 2
receptor Taq1A C> T polymorphism', for associations with the risk of opiate addiction and the
methadone dosage requirements. Methods Allelic frequencies of DRD2/ANKK1
polymorphisms were compared between 85 methadone-substituted Caucasian patients and …
