Population-specific effects of the Asn40Asp polymorphism at the μ-opioid receptor gene (OPRM1) on HPA-axis activation
CA Hernandez-Avila, J Covault, G Wand… - Pharmacogenetics …, 2007 - journals.lww.com
Background Studies in European Americans (EAs) have shown that the hypothalamic–
pituitary–adrenal (HPA)-axis activation by the opioid blockade is moderated by the single
nucleotide polymorphism (SNP) A118G (Asn40Asp) at the μ-opioid receptor locus (OPRM1).
We examined the effect of this, and of five intronic OPRM1 SNPs, on adrenocorticotropic
hormone and cortisol concentrations, following the placebo-controlled administration of
naloxone to healthy individuals who were of EA or Asian ancestry. Methods We used a …
pituitary–adrenal (HPA)-axis activation by the opioid blockade is moderated by the single
nucleotide polymorphism (SNP) A118G (Asn40Asp) at the μ-opioid receptor locus (OPRM1).
We examined the effect of this, and of five intronic OPRM1 SNPs, on adrenocorticotropic
hormone and cortisol concentrations, following the placebo-controlled administration of
naloxone to healthy individuals who were of EA or Asian ancestry. Methods We used a …
