[HTML][HTML] The cardiac determination factor, Nkx2-5, is activated by mutual cofactors GATA-4 and Smad1/4 via a novel upstream enhancer
CO Brown, X Chi, E Garcia-Gras, M Shirai… - Journal of Biological …, 2004 - ASBMB
The mammalian homologue of Drosophila tinman, Nkx2-5, plays an early role in regulating
cardiac genes and morphogenesis. Bone morphogenetic proteins (BMPs), members of the
transforming growth factor (TGF)-β family of signaling molecules, are involved in numerous
developmental processes. BMP signaling is crucial in the regulation of Nkx2-5 expression
and specification of the cardiac lineage. Constitutively active BMP type I receptor or the
downstream pathway components and DNA-binding transcription factors, Smad1/4 directly …
cardiac genes and morphogenesis. Bone morphogenetic proteins (BMPs), members of the
transforming growth factor (TGF)-β family of signaling molecules, are involved in numerous
developmental processes. BMP signaling is crucial in the regulation of Nkx2-5 expression
and specification of the cardiac lineage. Constitutively active BMP type I receptor or the
downstream pathway components and DNA-binding transcription factors, Smad1/4 directly …