[HTML][HTML] PHOX2B regulates its own expression by a transcriptional auto-regulatory mechanism
The specification of neuronal identity is a result of interactions between the following two
distinct classes of determinants: extrinsic factors that include secreted or cell membrane-
associated signals in the local environment, and intrinsic factors that generally consist of
ordered cascades of transcription factors. Little is known about the molecular mechanisms
underlying the interplay between these extrinsic and intrinsic factors and the transcriptional
processes that establish and maintain a given neuronal phenotype. Phox2b is a vertebrate …
distinct classes of determinants: extrinsic factors that include secreted or cell membrane-
associated signals in the local environment, and intrinsic factors that generally consist of
ordered cascades of transcription factors. Little is known about the molecular mechanisms
underlying the interplay between these extrinsic and intrinsic factors and the transcriptional
processes that establish and maintain a given neuronal phenotype. Phox2b is a vertebrate …