[HTML][HTML] Apolipoprotein B-containing lipoproteins in retinal aging and age-related macular degeneration

CA Curcio, M Johnson, JD Huang, M Rudolf - Journal of lipid research, 2010 - ASBMB
The largest risk factor for age-related macular degeneration (ARMD) is advanced age. With
aging, there is a striking accumulation of neutral lipids in Bruch's membrane (BrM) of normal
eye that continues through adulthood. This accumulation has the potential to significantly
impact the physiology of the retinal pigment epithelium (RPE). It also ultimately leads to the
creation of a lipid wall at the same locations where drusen and basal linear deposit, the
pathognomonic extracellular, lipid-containing lesions of ARMD, subsequently form. Here, we …