[HTML][HTML] Differential expression and function of ABCG1 and ABCG4 during development and aging [S]
DD Bojanic, PT Tarr, GD Gale, DJ Smith, D Bok… - Journal of lipid …, 2010 - ASBMB
ABCG1 and ABCG4 are highly homologous members of the ATP binding cassette (ABC)
transporter family that regulate cellular cholesterol homeostasis. In adult mice, ABCG1 is
known to be expressed in numerous cell types and tissues, whereas ABCG4 expression is
limited to the central nervous system (CNS). Here, we show significant differences in
expression of these two transporters during development. Examination of β-galactosidase-
stained tissue sections from Abcg1−/− LacZ and Abcg4−/− LacZ knockin mice shows that …
transporter family that regulate cellular cholesterol homeostasis. In adult mice, ABCG1 is
known to be expressed in numerous cell types and tissues, whereas ABCG4 expression is
limited to the central nervous system (CNS). Here, we show significant differences in
expression of these two transporters during development. Examination of β-galactosidase-
stained tissue sections from Abcg1−/− LacZ and Abcg4−/− LacZ knockin mice shows that …