Epidermal growth factor and transforming growth factor-α actions on the gut
RA Goodlad, NA Wright - European journal of gastroenterology & …, 1995 - journals.lww.com
Epidermal growth factor (EGF) and transforming growth factor-[alpha](TGF-[alpha]) are part
of a large family of ligands that bind to the epidermal growth factor receptor. While the
precise role of these ligands is still unclear, there is little doubt that they play an important
role in the development and maintenance of gastrointestinal epithelial continuity. The main
ligand for the intestinal EGF receptor (EGFR) may in fact be TGF-[alpha], and there is
evidence that EGF itself may act as a surveillance factor in adults, only having an effect if the …
of a large family of ligands that bind to the epidermal growth factor receptor. While the
precise role of these ligands is still unclear, there is little doubt that they play an important
role in the development and maintenance of gastrointestinal epithelial continuity. The main
ligand for the intestinal EGF receptor (EGFR) may in fact be TGF-[alpha], and there is
evidence that EGF itself may act as a surveillance factor in adults, only having an effect if the …