[HTML][HTML] Ligand-induced, p38-dependent apoptosis in cells expressing high levels of epidermal growth factor receptor and ErbB-2
O Tikhomirov, G Carpenter - Journal of Biological Chemistry, 2004 - ASBMB
Increased expression of the epidermal growth factor (EGF) receptor (EGFR) and ErbB-2 is
implicated into the development and progression of breast cancer. Constant ligand-induced
activation of EGFR and ErbB-2 receptor-tyrosine kinases is thought to be involved in the
transformation of fibroblasts and mammary epithelial cells. Data herein show that ligand
stimulation of cells that express both the EGFR and the ErbB-2 may result either in cell
proliferation or apoptosis depending on the expression levels of EGFR and ErbB-2 …
implicated into the development and progression of breast cancer. Constant ligand-induced
activation of EGFR and ErbB-2 receptor-tyrosine kinases is thought to be involved in the
transformation of fibroblasts and mammary epithelial cells. Data herein show that ligand
stimulation of cells that express both the EGFR and the ErbB-2 may result either in cell
proliferation or apoptosis depending on the expression levels of EGFR and ErbB-2 …