[HTML][HTML] Identification of the ligand binding site for the integrin α9β1 in the third fibronectin type III repeat of tenascin-C
Y Yokosaki, N Matsuura, S Higashiyama… - Journal of Biological …, 1998 - ASBMB
The integrin α 9 subunit forms a single heterodimer, α 9 β 1 that mediates cell adhesion to a
site within the third fibronectin type III repeat of tenascin-C (TNfn3). In contrast to at least 3
other integrins that bind to this region of tenascin-C, α 9 β 1 does not recognize the common
integrin recognition motif, Arg-Gly-Asp (RGD). In this report, we have used substitution
mutagenesis to identify a unique ligand recognition sequence in TNfn3. We introduced
mutations substituting alanine for each of the acidic residues in or adjacent to each of the …
site within the third fibronectin type III repeat of tenascin-C (TNfn3). In contrast to at least 3
other integrins that bind to this region of tenascin-C, α 9 β 1 does not recognize the common
integrin recognition motif, Arg-Gly-Asp (RGD). In this report, we have used substitution
mutagenesis to identify a unique ligand recognition sequence in TNfn3. We introduced
mutations substituting alanine for each of the acidic residues in or adjacent to each of the …