Identification and molecular characterization of multiple phenotypes in integrin knockout mice
C Chen, D Sheppard - Methods in enzymology, 2007 - Elsevier
Each of the 24 known integrin subunits has now been inactivated in mice, and a growing
number of conditional null lines are becoming available. Lines of mice expressing null
mutations in integrin subunit genes have taught us a great deal about the remarkably
diverse functions that integrins perform in vivo in mammals. Thorough evaluation of the
phenotypes manifested by these lines has also revealed a number of previously unexpected
integrin ligands and signaling partners. In this article, we review approaches that can …
number of conditional null lines are becoming available. Lines of mice expressing null
mutations in integrin subunit genes have taught us a great deal about the remarkably
diverse functions that integrins perform in vivo in mammals. Thorough evaluation of the
phenotypes manifested by these lines has also revealed a number of previously unexpected
integrin ligands and signaling partners. In this article, we review approaches that can …