[HTML][HTML] Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP)
M You, M Fischer, MA Deeg, DW Crabb - Journal of Biological Chemistry, 2002 - ASBMB
Alcoholic fatty liver is the earliest and most common response of the liver to alcohol and may
be a precursor of more severe forms of liver injury. The mechanism by which ethanol causes
fatty liver and liver injury is complex. We found that in both rat H4IIEC3 and McA-RH7777
hepatoma cell lines, ethanol induced transcription of a sterol regulatory element-binding
protein (SREBP)-regulated promoter via increased levels of mature SREBP-1 protein. This
effect of ethanol was blocked by addition of sterols. This effect is likely mediated by …
be a precursor of more severe forms of liver injury. The mechanism by which ethanol causes
fatty liver and liver injury is complex. We found that in both rat H4IIEC3 and McA-RH7777
hepatoma cell lines, ethanol induced transcription of a sterol regulatory element-binding
protein (SREBP)-regulated promoter via increased levels of mature SREBP-1 protein. This
effect of ethanol was blocked by addition of sterols. This effect is likely mediated by …