[HTML][HTML] Time of day and nutrients in feeding govern daily expression rhythms of the gene for sterol regulatory element-binding protein (SREBP)-1 in the mouse liver
E Matsumoto, A Ishihara, S Tamai, A Nemoto… - Journal of Biological …, 2010 - ASBMB
Sterol regulatory element-binding protein-1 (SREBP-1) plays a central role in transcriptional
regulation of genes for hepatic lipid synthesis that utilizes diet-derived nutrients such as
carbohydrates and amino acids, and expression of SREBP-1 exhibits daily rhythms with a
peak in the nocturnal feeding period under standard housing conditions of mice. Here, we
report that the Srebp-1 expression rhythm shows time cue-independent and Clock mutation-
sensitive circadian nature, and is synchronized with varied photoperiods apparently through …
regulation of genes for hepatic lipid synthesis that utilizes diet-derived nutrients such as
carbohydrates and amino acids, and expression of SREBP-1 exhibits daily rhythms with a
peak in the nocturnal feeding period under standard housing conditions of mice. Here, we
report that the Srebp-1 expression rhythm shows time cue-independent and Clock mutation-
sensitive circadian nature, and is synchronized with varied photoperiods apparently through …