[HTML][HTML] Insulin enhances the biogenesis of nuclear sterol regulatory element-binding protein (SREBP)-1c by posttranscriptional down-regulation of Insig-2A and its …
CR Yellaturu, X Deng, EA Park, R Raghow… - Journal of biological …, 2009 - ASBMB
The regulation of lipid homeostasis by insulin is mediated in part by the enhanced
transcription of the gene encoding sterol regulatory element-binding protein-1c (SREBP-1c).
The nascent SREBP-1c is embedded in the endoplasmic reticulum (ER) and must be
transported to the Golgi where two sequential cleavages generate its NH 2-terminal
fragment, nSREBP-1c. We have shown recently that in primary cultures of rat hepatocytes,
insulin rapidly and selectively stimulates proteolytic processing of the nascent SREBP-1c by …
transcription of the gene encoding sterol regulatory element-binding protein-1c (SREBP-1c).
The nascent SREBP-1c is embedded in the endoplasmic reticulum (ER) and must be
transported to the Golgi where two sequential cleavages generate its NH 2-terminal
fragment, nSREBP-1c. We have shown recently that in primary cultures of rat hepatocytes,
insulin rapidly and selectively stimulates proteolytic processing of the nascent SREBP-1c by …