[HTML][HTML] Improved statistical methods for hit selection in high-throughput screening
C Brideau, B Gunter, B Pikounis, A Liaw - SLAS Discovery, 2003 - Elsevier
High-throughput screening (HTS) plays a central role in modern drug discovery, allowing the
rapid screening of large compound collections against a variety of putative drug targets. HTS
is an industrial-scale process, relying on sophisticated auto mation, control, and state-of-the
art detection technologies to organize, test, and measure hundreds of thousands to millions
of compounds in nano-to microliter volumes. Despite this high technology, hit selection for
HTS is still typically done using simple data analysis and basic statistical methods. The …
rapid screening of large compound collections against a variety of putative drug targets. HTS
is an industrial-scale process, relying on sophisticated auto mation, control, and state-of-the
art detection technologies to organize, test, and measure hundreds of thousands to millions
of compounds in nano-to microliter volumes. Despite this high technology, hit selection for
HTS is still typically done using simple data analysis and basic statistical methods. The …