[HTML][HTML] Regulation of FOXO3a/β-catenin/GSK-3β signaling by 3, 3′-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in …
Y Li, Z Wang, D Kong, S Murthy, QP Dou… - Journal of Biological …, 2007 - ASBMB
Previous studies from our laboratory have shown anti-proliferative and pro-apoptotic effects
of 3, 3′-diindolylmethane (DIM) through regulation of Akt and androgen receptor (AR) in
prostate cancer cells. However, the mechanism by which DIM regulates Akt and AR
signaling pathways has not been fully investigated. It has been known that FOXO3a and
glycogen synthase kinase-3β (GSK-3β), two targets of activated Akt, interact with β-catenin,
regulating cell proliferation and apoptotic cell death. More importantly, FOXO3a, GSK-3β …
of 3, 3′-diindolylmethane (DIM) through regulation of Akt and androgen receptor (AR) in
prostate cancer cells. However, the mechanism by which DIM regulates Akt and AR
signaling pathways has not been fully investigated. It has been known that FOXO3a and
glycogen synthase kinase-3β (GSK-3β), two targets of activated Akt, interact with β-catenin,
regulating cell proliferation and apoptotic cell death. More importantly, FOXO3a, GSK-3β …