Signaling transduction: target in osteoarthritis
F Berenbaum - Current opinion in rheumatology, 2004 - journals.lww.com
Current opinion in rheumatology, 2004•journals.lww.com
Targeting signaling pathways in osteoarthritis did not seem feasible a few years ago
because of the complexity of the multiple intracellular pathways, mainly physiologic, defined
by a high degree of redundancy and cross-talk. However, important advances in the
knowledge of chondrocyte and synoviocyte signaling in osteoarthritis have been achieved in
recent years and suggest that inhibitors of specific signaling pathways could shortly provide
effective treatments for this disease.
because of the complexity of the multiple intracellular pathways, mainly physiologic, defined
by a high degree of redundancy and cross-talk. However, important advances in the
knowledge of chondrocyte and synoviocyte signaling in osteoarthritis have been achieved in
recent years and suggest that inhibitors of specific signaling pathways could shortly provide
effective treatments for this disease.
Summary
Targeting signaling pathways in osteoarthritis did not seem feasible a few years ago because of the complexity of the multiple intracellular pathways, mainly physiologic, defined by a high degree of redundancy and cross-talk. However, important advances in the knowledge of chondrocyte and synoviocyte signaling in osteoarthritis have been achieved in recent years and suggest that inhibitors of specific signaling pathways could shortly provide effective treatments for this disease.
Lippincott Williams & Wilkins