Senescence is now established as a genetically controlled phenomenon that alters different
cell functions, including proliferation, apoptosis, resistance to stress, and energetic
metabolism. Underlying changes in gene expression are governed by some transcription
factors, whose expression or activity must change with senescence as well. Transcription
factors of the Rel/NF-κB family are good candidates to participate in the establishment of
senescence. Arguments range from correlation between cell functions controlled by these …