[HTML][HTML] Human host genetic factors in mycobacterial and Salmonella infection: lessons from single gene disorders in IL-12/IL-23-dependent signaling that affect …
E Van de Vosse, THM Ottenhoff - Microbes and infection, 2006 - Elsevier
Interleukin (IL)-12/IL-23 signal transduction-deficient individuals with genetic defects in
IL12RB1 or IL12B often suffer from unusual mycobacterial and Salmonella infections. Here
we discuss recent questions that have arisen from clinical observations that cast doubt on
the necessity of IL-12/IL-23 signaling in controlling infections with intracellular bacteria.
Alternative IL-12/IL-23-dependent, interferon-γ-independent pathways of immunity to
intracellular bacteria are also discussed.
IL12RB1 or IL12B often suffer from unusual mycobacterial and Salmonella infections. Here
we discuss recent questions that have arisen from clinical observations that cast doubt on
the necessity of IL-12/IL-23 signaling in controlling infections with intracellular bacteria.
Alternative IL-12/IL-23-dependent, interferon-γ-independent pathways of immunity to
intracellular bacteria are also discussed.
