[HTML][HTML] Altered macrophage function is associated with severe Burkholderia pseudomallei infection in a murine model of type 2 diabetes
This study used a murine model of type 2 diabetes (BKS. Cg-Dock7m+/+ Leprdb/J mice) to
investigate the inflammatory and cellular mechanisms predisposing to Burkholderia
pseudomallei infection and co-morbid diabetes. Homozygous db/db (diabetic) mice
developed extreme obesity, dyslipidaemia and glucose intolerance leading to
hyperglycaemia and overt type 2 diabetes. Compared to their heterozygous db/+(non-
diabetic) littermates, diabetic mice rapidly succumbed to subcutaneous B. pseudomallei …
investigate the inflammatory and cellular mechanisms predisposing to Burkholderia
pseudomallei infection and co-morbid diabetes. Homozygous db/db (diabetic) mice
developed extreme obesity, dyslipidaemia and glucose intolerance leading to
hyperglycaemia and overt type 2 diabetes. Compared to their heterozygous db/+(non-
diabetic) littermates, diabetic mice rapidly succumbed to subcutaneous B. pseudomallei …
