Fibroblast growth factors: key players in epithelial morphogenesis, repair and cytoprotection
H Steiling, S Werner - Current opinion in biotechnology, 2003 - Elsevier
H Steiling, S Werner
Current opinion in biotechnology, 2003•ElsevierFibroblast growth factors (FGFs) regulate early development and organogenesis. In
particular, a subfamily of FGFs is essential for the formation and differentiation of epithelial
tissues and organs. Recent studies revealed a crucial role for these FGFs in repair of the
skin, intestine and liver. In addition, the cytoprotective potential of FGFs suggests their use
for the protection of epithelial cells under conditions of stress in vivo. Indeed, the first
successful clinical trials using FGFs for the treatment of radiation-and chemotherapy …
particular, a subfamily of FGFs is essential for the formation and differentiation of epithelial
tissues and organs. Recent studies revealed a crucial role for these FGFs in repair of the
skin, intestine and liver. In addition, the cytoprotective potential of FGFs suggests their use
for the protection of epithelial cells under conditions of stress in vivo. Indeed, the first
successful clinical trials using FGFs for the treatment of radiation-and chemotherapy …
Fibroblast growth factors (FGFs) regulate early development and organogenesis. In particular, a subfamily of FGFs is essential for the formation and differentiation of epithelial tissues and organs. Recent studies revealed a crucial role for these FGFs in repair of the skin, intestine and liver. In addition, the cytoprotective potential of FGFs suggests their use for the protection of epithelial cells under conditions of stress in vivo. Indeed, the first successful clinical trials using FGFs for the treatment of radiation- and chemotherapy-induced mucosal epithelial damage have been announced.
Elsevier