Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial

KM Sanders, AL Stuart, EJ Williamson, JA Simpson… - Jama, 2010 - jamanetwork.com
Context Improving vitamin D status may be an important modifiable risk factor to reduce falls
and fractures; however, adherence to daily supplementation is typically poor. Objective To
determine whether a single annual dose of 500 000 IU of cholecalciferol administered orally
to older women in autumn or winter would improve adherence and reduce the risk of falls
and fracture. Design, Setting, and Participants A double-blind, placebo-controlled trial of
2256 community-dwelling women, aged 70 years or older, considered to be at high risk of …