[HTML][HTML] Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9
MH Tatham, E Jaffray, OA Vaughan… - Journal of Biological …, 2001 - ASBMB
Conjugation of the small ubiquitin-like modifier SUMO-1/SMT3C/Sentrin-1 to proteins in vitro
is dependent on a heterodimeric E1 (SAE1/SAE2) and an E2 (Ubc9). Although SUMO-
2/SMT3A/Sentrin-3 and SUMO-3/SMT3B/Sentrin-2 share 50% sequence identity with SUMO-
1, they are functionally distinct. Inspection of the SUMO-2 and SUMO-3 sequences indicates
that they both contain the sequence ψKXE, which represents the consensus SUMO
modification site. As a consequence SAE1/SAE2 and Ubc9 catalyze the formation of …
is dependent on a heterodimeric E1 (SAE1/SAE2) and an E2 (Ubc9). Although SUMO-
2/SMT3A/Sentrin-3 and SUMO-3/SMT3B/Sentrin-2 share 50% sequence identity with SUMO-
1, they are functionally distinct. Inspection of the SUMO-2 and SUMO-3 sequences indicates
that they both contain the sequence ψKXE, which represents the consensus SUMO
modification site. As a consequence SAE1/SAE2 and Ubc9 catalyze the formation of …