[HTML][HTML] Parkinsonian mimetics induce aspects of unfolded protein response in death of dopaminergic neurons
WA Holtz, KL O'Malley - Journal of Biological Chemistry, 2003 - ASBMB
Genes associated with Parkinson's disease (PD) have suggested a role for ubiquitin-
proteasome dysfunction and aberrant protein degradation in this disorder. Inasmuch as
oxidative stress has also been implicated in PD, the present study examined transcriptional
changes mediated by the Parkinsonism-inducing neurotoxins 6-hydroxydopamine (6-
OHDA) and 1-methyl-4-phenylpyridinium (MPP+) in a dopaminergic cell line. Microarray
analysis of RNA isolated from toxin treated samples revealed that the stress-induced …
proteasome dysfunction and aberrant protein degradation in this disorder. Inasmuch as
oxidative stress has also been implicated in PD, the present study examined transcriptional
changes mediated by the Parkinsonism-inducing neurotoxins 6-hydroxydopamine (6-
OHDA) and 1-methyl-4-phenylpyridinium (MPP+) in a dopaminergic cell line. Microarray
analysis of RNA isolated from toxin treated samples revealed that the stress-induced …