[HTML][HTML] Helicobacter pylori CagA—a potential bacterial oncoprotein that functionally mimics the mammalian Gab family of adaptor proteins
M Hatakeyama - Microbes and infection, 2003 - Elsevier
Helicobacter pylori virulence factor CagA is injected into gastric epithelial cells and
undergoes tyrosine phosphorylation. Similar to mammalian Gab protein, tyrosine-
phosphorylated CagA recruits and activates SHP-2 phosphatase at the plasma membrane,
thereby inducing a growth factor-like effect. CagA–SHP-2 interaction may play an important
role in bacterial pathogenesis, leading to gastric carcinoma.
undergoes tyrosine phosphorylation. Similar to mammalian Gab protein, tyrosine-
phosphorylated CagA recruits and activates SHP-2 phosphatase at the plasma membrane,
thereby inducing a growth factor-like effect. CagA–SHP-2 interaction may play an important
role in bacterial pathogenesis, leading to gastric carcinoma.