Preferential expression and function of Toll-like receptor 3 in human astrocytes
C Farina, M Krumbholz, T Giese, G Hartmann… - Journal of …, 2005 - Elsevier
In contrast to other tissues, the central nervous system (CNS) is essentially devoid of MHC
expression and shielded from antibodies by the blood–brain barrier. Therefore, a rapid local
innate immune response by resident brain cells is required to effectively fight infectious
agents. This study analyzed the expression and function of Toll-like receptors (TLRs) in
cultured human astrocytes. Quantitative PCR for TLRs 1 to 10 showed a basal expression of
TLR3 that could be enhanced by IFN-γ, IL-1β, and IFN-β. The other TLRs were barely …
expression and shielded from antibodies by the blood–brain barrier. Therefore, a rapid local
innate immune response by resident brain cells is required to effectively fight infectious
agents. This study analyzed the expression and function of Toll-like receptors (TLRs) in
cultured human astrocytes. Quantitative PCR for TLRs 1 to 10 showed a basal expression of
TLR3 that could be enhanced by IFN-γ, IL-1β, and IFN-β. The other TLRs were barely …