[HTML][HTML] Multiple splice variants of the human HIF-3α locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex
MA Maynard, H Qi, J Chung, EHL Lee, Y Kondo… - Journal of Biological …, 2003 - ASBMB
Functional inactivation of the von Hippel-Lindau (VHL) tumor suppressor protein is the
cause of familial VHL disease and sporadic kidney cancer. The VHL gene product (pVHL) is
a component of an E3 ubiquitin ligase complex that targets the hypoxia-inducible factor (HIF)
1 and 2 α subunits for polyubiquitylation. This process is dependent on the hydroxylation of
conserved proline residues on the α subunits of HIF-1/2 in the presence of oxygen. In our
effort to identify orphan HIF-like proteins in the data base that are potential targets of the …
cause of familial VHL disease and sporadic kidney cancer. The VHL gene product (pVHL) is
a component of an E3 ubiquitin ligase complex that targets the hypoxia-inducible factor (HIF)
1 and 2 α subunits for polyubiquitylation. This process is dependent on the hydroxylation of
conserved proline residues on the α subunits of HIF-1/2 in the presence of oxygen. In our
effort to identify orphan HIF-like proteins in the data base that are potential targets of the …