[HTML][HTML] Excess peroxisomes are degraded by autophagic machinery in mammals

J Iwata, J Ezaki, M Komatsu, S Yokota, T Ueno… - Journal of Biological …, 2006 - ASBMB
Peroxisomes are degraded by autophagic machinery termed" pexophagy" in yeast;
however, whether this is essential for peroxisome degradation in mammals remains
unknown. Here we have shown that Atg7, an essential gene for autophagy, plays a pivotal
role in the degradation of excess peroxisomes in mammals. Following induction of
peroxisomes by a 2-week treatment with phthalate esters in control and Atg7-deficient livers,
peroxisomal degradation was monitored within 1 week after discontinuation of phthalate …