[HTML][HTML] Conserved role for 14-3-3ϵ downstream of type I TGFβ receptors

S McGonigle, MJ Beall, EL Feeney, EJ Pearce - FEBS letters, 2001 - Elsevier
S McGonigle, MJ Beall, EL Feeney, EJ Pearce
FEBS letters, 2001Elsevier
Schistosoma mansoni receptor kinase-1 (SmRK1) is a divergent type I transforming growth
factor β (TGFβ) receptor on the surface of adult parasites. Using the intracellular domain of
SmRK1 as bait in a yeast two-hybrid screen we identified an interaction with S. mansoni 14-
3-3ϵ. The interaction which is phosphorylation-dependent is not specific to schistosomes
since 14-3-3ϵ also binds to TβRI, the human type I TGFβ receptor. 14-3-3ϵ enhances TGFβ-
mediated signaling by TβRI and is the first TβRI-interacting non-Smad protein identified that …
Schistosoma mansoni receptor kinase-1 (SmRK1) is a divergent type I transforming growth factor β (TGFβ) receptor on the surface of adult parasites. Using the intracellular domain of SmRK1 as bait in a yeast two-hybrid screen we identified an interaction with S. mansoni 14-3-3ϵ. The interaction which is phosphorylation-dependent is not specific to schistosomes since 14-3-3ϵ also binds to TβRI, the human type I TGFβ receptor. 14-3-3ϵ enhances TGFβ-mediated signaling by TβRI and is the first TβRI-interacting non-Smad protein identified that positively regulates this receptor. The interaction of 14-3-3ϵ with schistosome and human TβRI suggests a conserved, but previously unappreciated, role for this protein in TGFβ signaling pathways.
Elsevier