Identification of a member of the MAPKKK family as a potential mediator of TGF-β signal transduction

K Yamaguchi, K Shirakabe, H Shibuya, K Irie, I Oishi… - Science, 1995 - science.org
K Yamaguchi, K Shirakabe, H Shibuya, K Irie, I Oishi, N Ueno, T Taniguchi, E Nishida…
Science, 1995science.org
The mitogen-activated protein kinase (MAPK) pathway is a conserved eukaryotic signaling
module that converts receptor signals into various outputs. MAPK is activated through
phosphorylation by MAPK kinase (MAPKK), which is first activated by MAPKK kinase
(MAPKKK). A genetic selection based on a MAPK pathway in yeast was used to identify a
mouse protein kinase (TAK1) distinct from other members of the MAPKKK family. TAK1 was
shown to participate in regulation of transcription by transforming growth factor-β (TGF-β) …
The mitogen-activated protein kinase (MAPK) pathway is a conserved eukaryotic signaling module that converts receptor signals into various outputs. MAPK is activated through phosphorylation by MAPK kinase (MAPKK), which is first activated by MAPKK kinase (MAPKKK). A genetic selection based on a MAPK pathway in yeast was used to identify a mouse protein kinase (TAK1) distinct from other members of the MAPKKK family. TAK1 was shown to participate in regulation of transcription by transforming growth factor-β (TGF-β). Furthermore, kinase activity of TAK1 was stimulated in response to TGF-β and bone morphogenetic protein. These results suggest that TAK1 functions as a mediator in the signaling pathway of TGF-β superfamily members.
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