Betaglycan presents ligand to the TGFβ signaling receptor
Cell, 1993•cell.com
Transforming growth factor fl (TGFB) signals through a heteromeric protein kinase receptor
that has a limited ability to bind ligand. This limitation is overcome by the action of
betagiycan (TGFf3 type ill receptor), a separate TGFf3-binding membrane protein of
previously unknown function. Betaglycan presents TGF) t directly to the kinase subunit of the
signaling receptor, forming a high affinity ternary complex. Membrane betaglycan increases
TGFfl binding to the signaling receptor, enhances cell responsiveness to TGFfl, and …
that has a limited ability to bind ligand. This limitation is overcome by the action of
betagiycan (TGFf3 type ill receptor), a separate TGFf3-binding membrane protein of
previously unknown function. Betaglycan presents TGF) t directly to the kinase subunit of the
signaling receptor, forming a high affinity ternary complex. Membrane betaglycan increases
TGFfl binding to the signaling receptor, enhances cell responsiveness to TGFfl, and …
Summary
Transforming growth factor fl (TGFB) signals through a heteromeric protein kinase receptor that has a limited ability to bind ligand. This limitation is overcome by the action of betagiycan (TGFf3 type ill receptor), a separate TGFf3-binding membrane protein of previously unknown function. Betaglycan presents TGF) t directly to the kinase subunit of the signaling receptor, forming a high affinity ternary complex. Membrane betaglycan increases TGFfl binding to the signaling receptor, enhances cell responsiveness to TGFfl, and eliminates marked biological differences between TGFB isoforms. Thus, betagiycan is a direct regulator of TGFg access to the signaling receptors.
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