[HTML][HTML] HSulf-1 and HSulf-2 are potent inhibitors of myeloma tumor growth in vivo
Y Dai, Y Yang, V MacLeod, X Yue… - Journal of Biological …, 2005 - ASBMB
To participate as co-receptor in growth factor signaling, heparan sulfate must have specific
structural features. Recent studies show that when the levels of 6-O-sulfation of heparan
sulfate are diminished by the activity of extracellular heparan sulfate 6-O-endosulfatases
(Sulfs), fibroblast growth factor 2-, heparin binding epidermal growth factor-, and hepatocyte
growth factor-mediated signaling are attenuated. This represents a novel mechanism for
regulating cell growth, particularly within the tumor microenvironment where the Sulfs are …
structural features. Recent studies show that when the levels of 6-O-sulfation of heparan
sulfate are diminished by the activity of extracellular heparan sulfate 6-O-endosulfatases
(Sulfs), fibroblast growth factor 2-, heparin binding epidermal growth factor-, and hepatocyte
growth factor-mediated signaling are attenuated. This represents a novel mechanism for
regulating cell growth, particularly within the tumor microenvironment where the Sulfs are …