Iron overload increases hepatic development of Plasmodium yoelii in mice
J Goma, L Renia, F Miltgen, D Mazier - Parasitology, 1996 - cambridge.org
J Goma, L Renia, F Miltgen, D Mazier
Parasitology, 1996•cambridge.orgIron overload in BALB/c mice by treatment with ferric ammonium citrate promotes the hepatic
development of Plasmodium yoelii in vivo and in vitro. This was the result of increased
penetration of the parasite into hepatocytes since no effect was observed on parasite
transformation or maturation. These results could explain why in endemic regions iron
supplementation led, in certain studies, to an increase in clinical episodes of malaria and in
the prevalence of malaria infection.
development of Plasmodium yoelii in vivo and in vitro. This was the result of increased
penetration of the parasite into hepatocytes since no effect was observed on parasite
transformation or maturation. These results could explain why in endemic regions iron
supplementation led, in certain studies, to an increase in clinical episodes of malaria and in
the prevalence of malaria infection.
Iron overload in BALB/c mice by treatment with ferric ammonium citrate promotes the hepatic development of Plasmodium yoelii in vivo and in vitro. This was the result of increased penetration of the parasite into hepatocytes since no effect was observed on parasite transformation or maturation. These results could explain why in endemic regions iron supplementation led, in certain studies, to an increase in clinical episodes of malaria and in the prevalence of malaria infection.
Cambridge University Press