[HTML][HTML] Transforming growth factor (TGF)-β1 stimulates pulmonary fibrosis and inflammation via a Bax-dependent, Bid-activated pathway that involves matrix …

HR Kang, SJ Cho, CG Lee, RJ Homer… - Journal of biological …, 2007 - ASBMB
Fibrosis, apoptosis, and the exaggerated production of transforming growth factor (TGF)-β 1
are juxtaposed in a variety of pulmonary diseases including the interstitial lung diseases and
asthma. In these disorders, the relationships between these responses are not well defined.
In addition, the apoptosis pathways that contribute to these responses and the mechanism
(s) of their contribution have not been described. We hypothesized that BH3 domain-only
protein-induced apoptosis plays an important role in the pathogenesis of TGF-β 1-induced …