Oxygen homeostasis is a cornerstone of both the physiology and intermediary metabolism
systems. Despite the explosion of knowledge brought about by recombinant DNA
technology, links between classic physiology and molecular biology are often fragmentary
and tenuous. However, during the past decade, there has been enormous progress in
understanding adaptation to hypoxia at the molecular level. A growing number of
physiologically relevant genes are up-regulated by falling intracellular oxygen tension via a …