Pendrin modulates ENaC function by changing luminal HCO3−
V Pech, TD Pham, S Hong, AM Weinstein… - Journal of the …, 2010 - journals.lww.com
Abstract The epithelial Na+ channel, ENaC, and the Cl−/HCO 3− exchanger, pendrin,
mediate NaCl absorption within the cortical collecting duct and the connecting tubule.
Although pendrin and ENaC localize to different cell types, ENaC subunit abundance and
activity are lower in aldosterone-treated pendrin-null mice relative to wild-type mice.
Because pendrin mediates HCO 3− secretion, we asked if increasing distal delivery of HCO
3− through a pendrin-independent mechanism “rescues” ENaC function in pendrin-null …
mediate NaCl absorption within the cortical collecting duct and the connecting tubule.
Although pendrin and ENaC localize to different cell types, ENaC subunit abundance and
activity are lower in aldosterone-treated pendrin-null mice relative to wild-type mice.
Because pendrin mediates HCO 3− secretion, we asked if increasing distal delivery of HCO
3− through a pendrin-independent mechanism “rescues” ENaC function in pendrin-null …