[HTML][HTML] A novel role for the adaptor molecule CD2-associated protein in transforming growth factor-β-induced apoptosis
M Schiffer, P Mundel, AS Shaw… - Journal of Biological …, 2004 - ASBMB
CD2-associated protein (CD2AP) is an adaptor molecule involved in T cell receptor
signaling and podocyte homeostasis. CD2AP-deficient mice develop nephrotic syndrome
and renal failure caused by glomerulosclerosis. Here we report that increased transforming
growth factor-β1 (TGF-β1) expression and apoptosis were present in podocytes at the onset
of albuminuria and were followed by depletion of podocytes associated with progressive
focal-segmental glomerulosclerosis in CD2AP-/-mice. Conditionally immortalized podocytes …
signaling and podocyte homeostasis. CD2AP-deficient mice develop nephrotic syndrome
and renal failure caused by glomerulosclerosis. Here we report that increased transforming
growth factor-β1 (TGF-β1) expression and apoptosis were present in podocytes at the onset
of albuminuria and were followed by depletion of podocytes associated with progressive
focal-segmental glomerulosclerosis in CD2AP-/-mice. Conditionally immortalized podocytes …