Standardization and statistical approaches to therapeutic trials in the R6/2 mouse

E Hockly, B Woodman, A Mahal, CM Lewis… - Brain research bulletin, 2003 - Elsevier
The R6/2 mouse is the most widely used animal model of Huntington's disease (HD), a
genetic disorder causing movement disorders, personality changes, dementia, and
premature death, for which there is currently no effective therapy. Use of animal models to
assess novel therapeutic approaches to HD is currently a major focus of research. Progress
in this field will depend upon careful standardization of experimental protocols, and a
sophisticated statistical approach. Here we investigate the sources of phenotypic variability …