Evidence that helodermin, a newly extracted peptide from Gila monster venom, is a member of the secretin/VIP/PHI family of peptides with an original pattern of …
P Robberecht, M Waelbroeck, JP Dehaye, J Winand… - FEBS letters, 1984 - Elsevier
P Robberecht, M Waelbroeck, JP Dehaye, J Winand, A Vandermeers…
FEBS letters, 1984•ElsevierHelodermin, a newly isolated peptide from the venom of Gila monster (Heloderma
suspectum) was shown to stimulate the adenylate cyclase activity of rat pancreatic
membranes as effectively as secretin and VIP. It also increased cyclic AMP levels and
inhibited [125 I] VIP binding in rat pancreatic acini. Finally, helodermin activated adenylate
cyclase in membranes from rat heart, rat brain, and human heart, showing properties
analogous yet distinct from those of secretin, VIP and PHI.
suspectum) was shown to stimulate the adenylate cyclase activity of rat pancreatic
membranes as effectively as secretin and VIP. It also increased cyclic AMP levels and
inhibited [125 I] VIP binding in rat pancreatic acini. Finally, helodermin activated adenylate
cyclase in membranes from rat heart, rat brain, and human heart, showing properties
analogous yet distinct from those of secretin, VIP and PHI.
Abstract
Helodermin, a newly isolated peptide from the venom of Gila monster (Heloderma suspectum) was shown to stimulate the adenylate cyclase activity of rat pancreatic membranes as effectively as secretin and VIP. It also increased cyclic AMP levels and inhibited [125I]VIP binding in rat pancreatic acini. Finally, helodermin activated adenylate cyclase in membranes from rat heart, rat brain, and human heart, showing properties analogous yet distinct from those of secretin, VIP and PHI.
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