Low zone tolerance induced by systemic application of allergens inhibits Tc1-mediated skin inflammation
W Seidel-Guyenot, S Perschon, N Dechant, R Alt… - Journal of allergy and …, 2006 - Elsevier
BACKGROUND: The induction of tolerance may be a promising target of strategies aimed at
preventing harmful allergic diseases. Low zone tolerance (LZT), induced by epicutaneous
application of low doses of contact allergens, inhibits the development of TC1-mediated
contact hypersensitivity (CHS). OBJECTIVE: We evaluated the effect of systemic (oral,
intravenous) administration of low amounts of haptens on specific immune reactions and
tolerance induction. METHODS: By using the mouse model of LZT, we analyzed immune …
preventing harmful allergic diseases. Low zone tolerance (LZT), induced by epicutaneous
application of low doses of contact allergens, inhibits the development of TC1-mediated
contact hypersensitivity (CHS). OBJECTIVE: We evaluated the effect of systemic (oral,
intravenous) administration of low amounts of haptens on specific immune reactions and
tolerance induction. METHODS: By using the mouse model of LZT, we analyzed immune …