TNF-α-induced apoptosis in human naïve and memory CD8+ T cells in aged humans
S Gupta, S Gollapudi - Experimental gerontology, 2006 - Elsevier
Recently, human CD8+ T cells have been divided into naïve, central memory (TCM), and
two types of effector memory cells (TEM and TEMRA), which are phenotypically identified by
a set of cell surface molecules. In this investigation, we have compared the relative
sensitivity of these subsets to TNF-α-induced apoptosis in young and aged humans. Our
data show increased sensitivity of naïve and TCM CD8+ T cells from aged humans to TNF-α-
induced apoptosis as compared to young subjects. Both TEM and TEMRA CD8+ T cells from …
two types of effector memory cells (TEM and TEMRA), which are phenotypically identified by
a set of cell surface molecules. In this investigation, we have compared the relative
sensitivity of these subsets to TNF-α-induced apoptosis in young and aged humans. Our
data show increased sensitivity of naïve and TCM CD8+ T cells from aged humans to TNF-α-
induced apoptosis as compared to young subjects. Both TEM and TEMRA CD8+ T cells from …